Carboxylesterase: from drug metabolism to drug discovery
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چکیده
منابع مشابه
Human carboxylesterase 1: from drug metabolism to drug discovery.
Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of heroin and cocaine, and the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene. We have determined the crystal structures of hCE1 in complex with either the cocaine analogue homat...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2009
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.134.281